Beyond Longevity: A Deep Dive into the Molecular Pathways, X-Chromosome Genetics, and Hormonal Shifts That Increase Women's Vulnerability to Alzheimer's and Autoimmune CNS Disorders.
Introduction: The Disparity Beyond the Lifespan
It is a stark, undeniable truth: approximately two-thirds of all people living with Alzheimer's disease (AD) are women. While the higher average lifespan of women has historically been cited as the primary driver for this discrepancy, recent, high-impact research is challenging this simplistic explanation. The emerging consensus is that the female brain is not just older; it is differently susceptible due to a complex tapestry of female-specific mechanism of neurodegeneration woven from sex chromosomes, hormonal dynamics, and distinct inflammatory responses.
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| Sexual Dimorphism in the CNS: The intricate interplay of genetics and hormones creates a unique environment in the female brain, influencing both resilience and susceptibility to neurodegenerative diseases. |
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